- 准教授 ROBERT,Martin
研究概要
We study the simple model bacterium E. coli, through its genes, proteins and metabolites and how they interact in the living cell, especially in biofilms. We aim at a better understanding of bacterial metabolic function, a fundamental cellular process that is deeply connected to all other cellular activities. All energy and mass/molecular transformations happening in the cell are what metabolism is all about. We are also trying to better understand how metabolic function is reorganised during adaption to new environments, during growth in large colonies and biofilms, Finally, we hope to uncover how the dynamics of bacterial populations are shaped by cell-cell and metabolic interactions.
While these are fundamental research objectives, they have broad potential applications for metabolic engineering and human/animal health because E. coli is a major ally for bio-production and for human digestive and metabolic function.
With E. coli we can perform experiments safely, rapidly, and conveniently often in a matter of hours or days, a task that could otherwise take weeks, months, if not years, using most other organisms. Moreover, basic functional discoveries made in E. coli can usually apply to most other living organisms.
主要論文
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Cheng K.K., Lee B-S., Masuda T., Fujikura J., Ito T., Ikeda K., Deng L., Dong J., Shimizu K., Soga T., Tomita M., Palsson B., and Robert M. (2014) Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol. Nat. Commun. 5:3233
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Saito, N., Robert, M., Kochi, H., Matsuo, G., Kakazu, Y., Soga, T., and Tomita, M. (2009) Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli. J. Biol. Chem. 284, 24, 16442–16451
- Ishii, N., Nakahigashi, K., Baba, T., Robert, M*., Soga, T., Kanai, A., Hirasawa, T., et al. (2007). Multiple High-Throughput Analyses Monitor the Response of E. coli to Perturbations. Science 316, 593-597. (*Equivalent contribution of first 7 authors)